Ultrasound Helps Identify Alcohol-Induced Liver Disease
By MedImaging International staff writers Posted on 30 Aug 2018 |
Ultrasound (US) findings can be used to identify liver damage in alcohol use disorder (AUD) patients and make more informed treatment decisions, claims a new study.
Researchers at the Autonomous University of Barcelona (UAB; Spain) and the Municipal Centre for Substance Abuse Treatment (Badalona, Spain) conducted a cross-sectional analysis of 301 AUD detoxification patients (80% male, median age 46 years), analyzing abdominal US scans in order to identify steatosis (fatty liver), hepatomegaly (liver enlargement), heterogeneous liver, and portal hypertension. Analytical liver injury was defined as aspartate aminotransferase (AST) levels between 74 and 300 units per liter (U/L), AST/alanine aminotransferase ratio of greater than 2, and total bilirubin of more than 1.2 milligrams per deciliter (mg/dL).
Among the patient cohort, prevalence of the hepatitis C virus was 21.2%, AST levels were 42 U/L, and ALT levels were 35 U/L (indicating liver enlargement or mild to moderate fatty liver disease); 16% of patients had analytical liver injury (ALI) and 24% had advanced liver fibrosis (ALF). US findings revealed that 57.2% had steatosis, 49.5% suffered from hepatomegaly, 17% had a heterogeneous liver, and 16% had portal hypertension. Of these, 77% had at least one US abnormality, and 45% had two or more. The study was published on July 19, 2018, in Drug and Alcohol Dependence.
“Liver damage is a major driver of disease burden in patients with unhealthy alcohol use, and liver disease is often diagnosed in advanced stages. Liver ultrasound appears to capture a significant proportion of mild to moderate abnormalities in patients who do not meet ALI or ALF criteria,” said lead author Daniel Fuster, MD, of UAB. “In this regard, the use of ultrasound to detect early stages of liver disease may promote alcohol cessation.”
Liver disease due to alcohol use can manifest in a variety of conditions, including acute alcoholic hepatitis, steatosis, steatohepatitis, cirrhosis of the liver, and hepatocarcinoma. Some of these can be reversed or mitigated if the patient quits drinking. For example, steatosis without inflammation can be reversed if drinking is stopped. Once steatohepatitis has been established, liver damage can't be fully reversed, but quitting alcohol can lessen portal hypertension. Alcoholic patients also tend to be more vulnerable to hepatitis C.
Related Links:
Autonomous University of Barcelona
Researchers at the Autonomous University of Barcelona (UAB; Spain) and the Municipal Centre for Substance Abuse Treatment (Badalona, Spain) conducted a cross-sectional analysis of 301 AUD detoxification patients (80% male, median age 46 years), analyzing abdominal US scans in order to identify steatosis (fatty liver), hepatomegaly (liver enlargement), heterogeneous liver, and portal hypertension. Analytical liver injury was defined as aspartate aminotransferase (AST) levels between 74 and 300 units per liter (U/L), AST/alanine aminotransferase ratio of greater than 2, and total bilirubin of more than 1.2 milligrams per deciliter (mg/dL).
Among the patient cohort, prevalence of the hepatitis C virus was 21.2%, AST levels were 42 U/L, and ALT levels were 35 U/L (indicating liver enlargement or mild to moderate fatty liver disease); 16% of patients had analytical liver injury (ALI) and 24% had advanced liver fibrosis (ALF). US findings revealed that 57.2% had steatosis, 49.5% suffered from hepatomegaly, 17% had a heterogeneous liver, and 16% had portal hypertension. Of these, 77% had at least one US abnormality, and 45% had two or more. The study was published on July 19, 2018, in Drug and Alcohol Dependence.
“Liver damage is a major driver of disease burden in patients with unhealthy alcohol use, and liver disease is often diagnosed in advanced stages. Liver ultrasound appears to capture a significant proportion of mild to moderate abnormalities in patients who do not meet ALI or ALF criteria,” said lead author Daniel Fuster, MD, of UAB. “In this regard, the use of ultrasound to detect early stages of liver disease may promote alcohol cessation.”
Liver disease due to alcohol use can manifest in a variety of conditions, including acute alcoholic hepatitis, steatosis, steatohepatitis, cirrhosis of the liver, and hepatocarcinoma. Some of these can be reversed or mitigated if the patient quits drinking. For example, steatosis without inflammation can be reversed if drinking is stopped. Once steatohepatitis has been established, liver damage can't be fully reversed, but quitting alcohol can lessen portal hypertension. Alcoholic patients also tend to be more vulnerable to hepatitis C.
Related Links:
Autonomous University of Barcelona
Latest Ultrasound News
- Groundbreaking Technology Enables Precise, Automatic Measurement of Peripheral Blood Vessels
- Deep Learning Advances Super-Resolution Ultrasound Imaging
- Novel Ultrasound-Launched Targeted Nanoparticle Eliminates Biofilm and Bacterial Infection
- AI-Guided Ultrasound System Enables Rapid Assessments of DVT
- Focused Ultrasound Technique Gets Quality Assurance Protocol
- AI-Guided Handheld Ultrasound System Helps Capture Diagnostic-Quality Cardiac Images
- Non-Invasive Ultrasound Imaging Device Diagnoses Risk of Chronic Kidney Disease
- Wearable Ultrasound Platform Paves Way for 24/7 Blood Pressure Monitoring On the Wrist
- Diagnostic Ultrasound Enhancing Agent to Improve Image Quality in Pediatric Heart Patients
- AI Detects COVID-19 in Lung Ultrasound Images
- New Ultrasound Technology to Revolutionize Respiratory Disease Diagnoses
- Dynamic Contrast-Enhanced Ultrasound Highly Useful For Interventions
- Ultrasensitive Broadband Transparent Ultrasound Transducer Enhances Medical Diagnosis
- Artificial Intelligence Detects Heart Defects in Newborns from Ultrasound Images
- Ultrasound Imaging Technology Allows Doctors to Watch Spinal Cord Activity during Surgery
- Shape-Shifting Ultrasound Stickers Detect Post-Surgical Complications