New Imaging Technology Detects Gastric Lymphomas
|
By MedImaging International staff writers Posted on 13 Oct 2021 |
|
Image: MALT lymphomas express the chemokine receptor CXCR4 (Photo courtesy of MedUni)
A new imaging technique for the detection of gastric mucosa-associated lymphoid tissue (MALT) lymphomas could reduce invasive gastroscopy biopsies, according to a new study.
The study, by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC; New York, NY, USA), the Medical University of Vienna (MedUni; Austria), and other institutions, explored if [68Ga]Pentixafor, a positron emission tomography (PET) tracer that targets the chemokine receptor CXCR4 (which is overexpressed in MALT lymphoma), could serve as a potential alternative to follow-up biopsies for assessment of residual disease following first-line H. pylori eradication.
The study, which included [68Ga]Pentixafor-PET and magnetic resonance imaging (MRI) scans in 26 gastric MALT lymphoma patients and 20 control group patients without lymphoma, showed that accuracy, sensitivity, specificity, and positive and negative predictive value of [68Ga]Pentixafor-PET for detection of residual gastric MALT lymphoma at follow-up were 97%, 95%, 100%, 100%, and 92.9%, respectively. Maximum and mean PET standardized uptake values also showed correlation with immunohistochemistry-based CXCR4 cell counts. The study was published on September 15, 2021, in Blood.
“Post-treatment evaluation of gastric MALT currently relies on esophagogastroduodenoscopy with histological assessment of biopsies,” concluded lead author Marius Mayerhöfer, PhD, of the MedUni department of biomedical imaging and image-guided therapy, and colleagues. “If a sufficiently high CXCR4 expression is detected at the initial diagnosis of MALT lymphoma, the new imaging could replace repeated gastroscopies in the course of the disease in the future, or at least increase the time intervals between gastroscopies.”
CXCR4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1), a molecule with potent chemotactic activity for lymphocytes. After attachment to SDF-1, the CXCR4 protein activates signaling pathways inside the cell that help regulate cell growth and proliferation. CXCR4 is also involved in cell migration cells, especially hematopoietic stem cells in the bone marrow.
Related Links:
Memorial Sloan-Kettering Cancer Center
Medical University of Vienna
The study, by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC; New York, NY, USA), the Medical University of Vienna (MedUni; Austria), and other institutions, explored if [68Ga]Pentixafor, a positron emission tomography (PET) tracer that targets the chemokine receptor CXCR4 (which is overexpressed in MALT lymphoma), could serve as a potential alternative to follow-up biopsies for assessment of residual disease following first-line H. pylori eradication.
The study, which included [68Ga]Pentixafor-PET and magnetic resonance imaging (MRI) scans in 26 gastric MALT lymphoma patients and 20 control group patients without lymphoma, showed that accuracy, sensitivity, specificity, and positive and negative predictive value of [68Ga]Pentixafor-PET for detection of residual gastric MALT lymphoma at follow-up were 97%, 95%, 100%, 100%, and 92.9%, respectively. Maximum and mean PET standardized uptake values also showed correlation with immunohistochemistry-based CXCR4 cell counts. The study was published on September 15, 2021, in Blood.
“Post-treatment evaluation of gastric MALT currently relies on esophagogastroduodenoscopy with histological assessment of biopsies,” concluded lead author Marius Mayerhöfer, PhD, of the MedUni department of biomedical imaging and image-guided therapy, and colleagues. “If a sufficiently high CXCR4 expression is detected at the initial diagnosis of MALT lymphoma, the new imaging could replace repeated gastroscopies in the course of the disease in the future, or at least increase the time intervals between gastroscopies.”
CXCR4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1), a molecule with potent chemotactic activity for lymphocytes. After attachment to SDF-1, the CXCR4 protein activates signaling pathways inside the cell that help regulate cell growth and proliferation. CXCR4 is also involved in cell migration cells, especially hematopoietic stem cells in the bone marrow.
Related Links:
Memorial Sloan-Kettering Cancer Center
Medical University of Vienna
Pocket Fetal Doppler
CONTEC10C/CL
Biopsy Software
Affirm® Contrast
Silver Member
X-Ray QA Meter
T3 AD Pro
Portable X-ray Unit
AJEX140H
Latest General/Advanced Imaging News
- CT Colonography Beats Stool DNA Testing for Colon Cancer Screening
- First-Of-Its-Kind Wearable Device Offers Revolutionary Alternative to CT Scans
- AI-Based CT Scan Analysis Predicts Early-Stage Kidney Damage Due to Cancer Treatments
- CT-Based Deep Learning-Driven Tool to Enhance Liver Cancer Diagnosis
- AI-Powered Imaging System Improves Lung Cancer Diagnosis
- AI Model Significantly Enhances Low-Dose CT Capabilities
- Ultra-Low Dose CT Aids Pneumonia Diagnosis in Immunocompromised Patients
- AI Reduces CT Lung Cancer Screening Workload by Almost 80%
- Cutting-Edge Technology Combines Light and Sound for Real-Time Stroke Monitoring
- AI System Detects Subtle Changes in Series of Medical Images Over Time
- New CT Scan Technique to Improve Prognosis and Treatments for Head and Neck Cancers
- World’s First Mobile Whole-Body CT Scanner to Provide Diagnostics at POC
- Comprehensive CT Scans Could Identify Atherosclerosis Among Lung Cancer Patients
- AI Improves Detection of Colorectal Cancer on Routine Abdominopelvic CT Scans
- Super-Resolution Technology Enhances Clinical Bone Imaging to Predict Osteoporotic Fracture Risk
- AI-Powered Abdomen Map Enables Early Cancer Detection
Channels
Radiography
view channel
AI Detects Fatty Liver Disease from Chest X-Rays
Fatty liver disease, which results from excess fat accumulation in the liver, is believed to impact approximately one in four individuals globally. If not addressed in time, it can progress to severe conditions... Read more
AI Detects Hidden Heart Disease in Existing CT Chest Scans
Coronary artery calcium (CAC) is a major indicator of cardiovascular risk, but its assessment typically requires a specialized “gated” CT scan that synchronizes with the heartbeat. In contrast, most chest... Read more
MRI
view channel
AI Model Outperforms Doctors at Identifying Patients Most At-Risk of Cardiac Arrest
Hypertrophic cardiomyopathy is one of the most common inherited heart conditions and a leading cause of sudden cardiac death in young individuals and athletes. While many patients live normal lives, some... Read more
New MRI Technique Reveals Hidden Heart Issues
Traditional exercise stress tests conducted within an MRI machine require patients to lie flat, a position that artificially improves heart function by increasing stroke volume due to gravity-driven blood... Read more
Ultrasound
view channel
Wireless Chronic Pain Management Device to Reduce Need for Painkillers and Surgery
Chronic pain affects millions of people globally, often leading to long-term disability and dependence on opioid medications, which carry significant risks of side effects and addiction.... Read more
New Medical Ultrasound Imaging Technique Enables ICU Bedside Monitoring
Ultrasound computed tomography (USCT) presents a safer alternative to imaging techniques like X-ray computed tomography (commonly known as CT or “CAT” scans) because it does not produce ionizing radiation.... Read more
.jpeg "Image: The AI-powered lung ultrasound tool outperformed human experts by 9% in diagnosing TB (Photo courtesy of Adobe Stock)")
Nuclear Medicine
view channel
Novel Bacteria-Specific PET Imaging Approach Detects Hard-To-Diagnose Lung Infections
Mycobacteroides abscessus is a rapidly growing mycobacteria that primarily affects immunocompromised patients and those with underlying lung diseases, such as cystic fibrosis or chronic obstructive pulmonary... Read more
New Imaging Approach Could Reduce Need for Biopsies to Monitor Prostate Cancer
Prostate cancer is the second leading cause of cancer-related death among men in the United States. However, the majority of older men diagnosed with prostate cancer have slow-growing, low-risk forms of... Read more
Imaging IT
view channel
New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible
Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more
Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology
The global artificial intelligence (AI) in medical diagnostics market is expanding with early disease detection being one of its key applications and image recognition becoming a compelling consumer proposition... Read more
Industry News
view channel
GE HealthCare and NVIDIA Collaboration to Reimagine Diagnostic Imaging
GE HealthCare (Chicago, IL, USA) has entered into a collaboration with NVIDIA (Santa Clara, CA, USA), expanding the existing relationship between the two companies to focus on pioneering innovation in... Read more
Patient-Specific 3D-Printed Phantoms Transform CT Imaging
New research has highlighted how anatomically precise, patient-specific 3D-printed phantoms are proving to be scalable, cost-effective, and efficient tools in the development of new CT scan algorithms... Read more
Siemens and Sectra Collaborate on Enhancing Radiology Workflows
Siemens Healthineers (Forchheim, Germany) and Sectra (Linköping, Sweden) have entered into a collaboration aimed at enhancing radiologists' diagnostic capabilities and, in turn, improving patient care... Read more