Fusion Imaging Technique Pinpoints Key Changes that Occur with Traumatic Brain Injury

Results from a study by French and Australian investigators revealed that powerful imaging techniques--positron emission tomography (PET) fused with magnetic resonance imaging (MRI)--are helping researchers better understand the long-term functional and structural changes that take place after traumatic brain injury (TBI).

"The results provide new insights into the progressive nature of the brain changes occurring following TBI, demonstrating that changes in brain structure and function after TBI are dynamic and continue to progress and evolve for months,” said Viviane Bouilleret, M.D., Ph.D., from the University Paris-Sud (France), one of the authors of the study.

The article, published in the November 2010 issue of the Journal of Nuclear Medicine (JNM), reported the first study to use repeated PET and MRI of live animals to characterize the long-term progressive functional and structural brain changes that occur following experimental TBI. The model used is the lateral fluid percussion-injury model in rats, the most widely utilized and confirmed animal model in fundamental TBI research. The images were evaluated using a variety of advanced image analysis approaches.

Widespread decreases in brain functioning were seen in specific brain regions, many of which are remote from the site of direct trauma and unaccompanied by signs of injury on the MRI. The hippocampus, a brain structure vital to memory and emotion, is the key area of these changes. This may have implications for the pathophysiology of some of the long-term neurologic and psychiatric morbidity, seen following TBI, even when abnormalities are not obvious on structural MRI. The severity of the neurologic deficits and alterations on MRI scans soon after the injury is predictive of severity of long-term neurodegenerative changes.

Traumatic brain injury is a leading cause of death and disability in children and young adults worldwide. Long-term disabilities following TBI include cognitive disabilities such as disorders in attention, memory, learning, and executive functioning; psychiatric and behavioral problems including depression, anxiety, aggression, agitation, and social inappropriateness; and epilepsy. Currently there are no effective interventions to reduce the incidence or severity of these problems.

The findings of this study indicate that secondary structural and functional changes in the brain continue to occur for many months post-TBI, which has implications for understanding the processes underlying the long-term neurologic and psychiatric consequences. Significantly, these findings indicate that there is a time window during which intervention could modulate these processes and mitigate against these disabling consequences of TBI.

This study has also provided a practical paradigm for testing the biologic effectiveness of potential therapies prior to embarking on expensive and lengthy clinical trials. "The approach would also be applicable to the study of other neurological diseases, such as stroke, dementia, multiple sclerosis brain infections, and epilepsy, which are associated with long-term progressive degenerative changes in the brain,” Dr. Bouilleret said.

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