Imaging, Genetic Testing Reveal that Tyrolean Iceman had Genetic Predisposition for Atherosclerosis
By MedImaging International staff writers Posted on 13 Aug 2014 |
Image: Reconstruction of the Iceman “Ötzi“ as presented in the South Tyrolean Archaeology Museum showing the Iceman with brown eyes based on the genetic analysis (Photo courtesy of the South Tyrol Museum of Archaeology, Photo Ochsenreiter).
Although prevalence and types of risk factors for atherosclerosis have varied over time from ancient times to modern society (such as levels of obesity, physical activity), genetic predisposition/risk for the disorder now appears to be very similar to that in ancient times, according to new imaging and genetic findings gleaned from a 300-year-old glacier mummy.
The study’s findings were published in the July 2014 issue of Global Heart, the journal of the World Heart Federation, authored by Prof. Albert Zink, Institute for Mummies and the Iceman, European Academy of Bolzano/Bozen (EURAC; Bolzano/Bozen, Italy), and colleagues.
Although advanced imaging techniques have been employed to identify atherosclerosis in the mummified remains of multiple cultures, evidence of genetic predisposition has been more difficult to gather because of the degradation of the genetic material over time. However, in an earlier whole-genome study of the Tyrolean Iceman, a 5,300-year-old glacier mummy from the Alps, an increased risk for coronary heart disease was detected. The Iceman’s genome revealed several single nucleotide polymorphisms (SNPs) that have been linked with modern day cardiovascular disease in the many genome-wide association studies that have been published across the past 10 years.
The remains of the Iceman have undergone extensive analysis, however for the purposes of this paper the most intriguing finding was that the Iceman showed a strong genetic predisposition for increased risk for coronary heart disease (CHD). This is of particular interest as the computed tomography (CT) imaging scans of the Iceman already had revealed major calcification in several major blood vessels, including the carotid arteries, distal aorta, and right iliac artery, which are strong signs of generalized atherosclerotic disease. The scientists reported that other standard cardiac risk factors, such as being overweight, tobacco smoking, lack of physical activity, and a high fat diet, can generally be ruled out in a person from this time period.
In particular, the genetic sequencing data demonstrates that the Iceman had a very specific genetic mutation, namely, that he was homozygous for the minor allele (GG) of rs10757274, located in chromosomal region 9p21. This SNP is currently regarded as being among the strongest genetic predictors of heart attacks and has been confirmed in several studies as a major risk locus for CHD.
Regarding the suggestion that human ancestors lived much cleaner and active lives, free from all risks of heart disease compared with modern day sedentary lifestyles, the authors commented: “Wrong. Our ancestors going back thousands of years show signs of atherosclerosis, as suggested by modern research using CT to detect evidence of calcium deposits associated with atherosclerotic plaques in the arteries of mummies as old as 5,000 years. Even though our human ancestors lived far different lives than we do, their environments and lifestyles were not protecting them against the development of atherosclerosis. What is similar between now and then is the human genetic material, our genome, including ancient polymorphisms that were uncovered to predispose the carrier to the development of atherosclerotic cardiovascular disease...however, our ancient ancestors were certainly susceptible to many other conditions, such as infectious diseases, nutritional deprivation, and trauma, which often resulted in death at an early age, before atherosclerotic heart disease had a clinical impact.”
The authors reported in their article, “Until now, the Iceman is the only ancient human remain in which a genetic predisposition for cardiovascular disease has been detected...future genetic studies of ancient humans from various geographic origins and time periods have the potential to provide more insights into the presence and possible changes of genetic risk factors in our ancestors. The study of ancient humans and a better understanding of the interaction between environmental and genetic influences on the development of heart diseases may lead to a more effective prevention and treatment of the most common cause of death in the modern world.”
Related Links:
European Academy of Bolzano/Bozen
The study’s findings were published in the July 2014 issue of Global Heart, the journal of the World Heart Federation, authored by Prof. Albert Zink, Institute for Mummies and the Iceman, European Academy of Bolzano/Bozen (EURAC; Bolzano/Bozen, Italy), and colleagues.
Although advanced imaging techniques have been employed to identify atherosclerosis in the mummified remains of multiple cultures, evidence of genetic predisposition has been more difficult to gather because of the degradation of the genetic material over time. However, in an earlier whole-genome study of the Tyrolean Iceman, a 5,300-year-old glacier mummy from the Alps, an increased risk for coronary heart disease was detected. The Iceman’s genome revealed several single nucleotide polymorphisms (SNPs) that have been linked with modern day cardiovascular disease in the many genome-wide association studies that have been published across the past 10 years.
The remains of the Iceman have undergone extensive analysis, however for the purposes of this paper the most intriguing finding was that the Iceman showed a strong genetic predisposition for increased risk for coronary heart disease (CHD). This is of particular interest as the computed tomography (CT) imaging scans of the Iceman already had revealed major calcification in several major blood vessels, including the carotid arteries, distal aorta, and right iliac artery, which are strong signs of generalized atherosclerotic disease. The scientists reported that other standard cardiac risk factors, such as being overweight, tobacco smoking, lack of physical activity, and a high fat diet, can generally be ruled out in a person from this time period.
In particular, the genetic sequencing data demonstrates that the Iceman had a very specific genetic mutation, namely, that he was homozygous for the minor allele (GG) of rs10757274, located in chromosomal region 9p21. This SNP is currently regarded as being among the strongest genetic predictors of heart attacks and has been confirmed in several studies as a major risk locus for CHD.
Regarding the suggestion that human ancestors lived much cleaner and active lives, free from all risks of heart disease compared with modern day sedentary lifestyles, the authors commented: “Wrong. Our ancestors going back thousands of years show signs of atherosclerosis, as suggested by modern research using CT to detect evidence of calcium deposits associated with atherosclerotic plaques in the arteries of mummies as old as 5,000 years. Even though our human ancestors lived far different lives than we do, their environments and lifestyles were not protecting them against the development of atherosclerosis. What is similar between now and then is the human genetic material, our genome, including ancient polymorphisms that were uncovered to predispose the carrier to the development of atherosclerotic cardiovascular disease...however, our ancient ancestors were certainly susceptible to many other conditions, such as infectious diseases, nutritional deprivation, and trauma, which often resulted in death at an early age, before atherosclerotic heart disease had a clinical impact.”
The authors reported in their article, “Until now, the Iceman is the only ancient human remain in which a genetic predisposition for cardiovascular disease has been detected...future genetic studies of ancient humans from various geographic origins and time periods have the potential to provide more insights into the presence and possible changes of genetic risk factors in our ancestors. The study of ancient humans and a better understanding of the interaction between environmental and genetic influences on the development of heart diseases may lead to a more effective prevention and treatment of the most common cause of death in the modern world.”
Related Links:
European Academy of Bolzano/Bozen
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